Component methods (CNMA and component PAIC)

35 open problems

Reconnecting a treatment-disconnected graph through shared components, and the cross-subnetwork constancy that makes it work or fail.

ID Problem Priority Verdict Maturity prank
CMP-01 Cross-subnetwork component constancy is the untestable bridge Very high Confirmed open Emerging 1
CMP-02 Adjusted component bridges need interaction constancy across the gap Very high Confirmed open Emerging 1
CMP-03 Strict component additivity may be clinically false Very high Partially addressed Emerging 1
CMP-05 No versioned intervention ontology maps onto CNMA component matrices Very high Overstated Emerging 1
CMP-08 Identification beyond row-space screens in nonlinear component ML-NMR Very high Partially addressed Emerging 1
CMP-09 cMAIC combines marginal effects through an additive component model Very high Confirmed open Promising 1
CMP-10 Component PAIC lacks a marginal target-standardized estimand path Very high Partially addressed Promising 1
CMP-11 Two-stage component PAIC adjusts only the IPD edges Very high Partially addressed Promising 1
CMP-13 Shared Gamma conflates within- and between-study modification Very high Overstated Promising 1
CMP-14 Aggregate-data-only interactions may be prior-driven Very high Partially addressed Promising 1
CMP-17 Survival pseudo-IPD reconstruction uncertainty is not propagated Very high Partially addressed Emerging 1
CMP-18 Proportional or time-constant component effects may fail Very high Partially addressed Promising 1
CMP-21 Missing data and MNAR sensitivity are unaddressed in component PAIC Very high Overstated Emerging 1
CMP-26 Unreleased cpaic has no tracked simulation benchmark or replication Very high Partially addressed Established 1
CMP-30 No diagnostic for anchor choice in additive component models Very high Confirmed open Emerging 1
CMP-04 Additivity model selection can be unstable High Partially addressed Promising 2
CMP-06 Measurement error and component misclassification are ignored High Partially addressed Emerging 2
CMP-07 Causal meaning of a component effect is ambiguous High Unverifiable Emerging 2
CMP-12 No two-stage adjusted estimator carries multi-arm covariance High Partially addressed Promising 2
CMP-15 Target joint covariate distribution is only approximately known High Unverifiable Emerging 2
CMP-16 Unreleased cpaic shares one tau and one IPD-row residual variance High Unverifiable Promising 2
CMP-19 Competing risks and recurrent events are absent from component PAIC High Confirmed open Emerging 2
CMP-20 Poisson aggregate likelihood needs zero exposure-rate covariance High Unverifiable Emerging 2
CMP-22 IPD availability may be informative rather than random High Partially addressed Emerging 2
CMP-23 Bridge fragility ignores interaction and correlated component drift High Overstated Emerging 2
CMP-25 Component ML-NMR integration has no parallel or adaptive scheme High Partially addressed Promising 2
CMP-28 Component NMA has no dose-response dimension High Partially addressed Emerging 2
CMP-29 No component-level transitivity and coherence assessment High Confirmed open Emerging 2
CMP-31 No practical-identification diagnostic for component effects High Confirmed open Promising 2
CMP-33 No screen separates randomized from between-study component identification High Confirmed open Promising 2
CMP-34 No sensitivity or reporting standard for discretionary component coding High Confirmed open Emerging 2
CMP-27 Component models cannot represent delivery order or sequencing Medium-high Confirmed open Emerging 3
CMP-32 No sample-size or allocation method for component NMA Medium-high Confirmed open Emerging 3
CMP-35 No unique definition of evidence contribution for component estimates Medium-high Confirmed open Emerging 3
CMP-24 Edge influence is approximate for multi-arm and random effects Medium Partially addressed Promising 4
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