Outcome-specific problems

26 open problems

Binary and rare events, continuous scales, counts, ordinal endpoints, time-to-event under non-proportional hazards, competing risks, and benefit–risk.

ID Problem Priority Verdict Maturity prank
OUT-01 Target-standardized marginal risks are not the HTA reporting default Very high Overstated Established 1
OUT-07 Informative censoring and outcome-dependent missingness Very high Partially addressed Promising 1
OUT-11 Non-proportional hazards and the transported hazard ratio Very high Overstated Promising 1
OUT-02 Rare events, separation, and zero-event studies in weighted synthesis High Partially addressed Promising 2
OUT-03 Outcome misclassification in binary indirect comparisons High Partially addressed Promising 2
OUT-04 Different instruments and standardized mean difference transport High Partially addressed Promising 2
OUT-08 Overdispersed counts and recurrent events as total disease burden High Unverifiable Emerging 2
OUT-09 Endogenous exposure time and target-standardized rate contrasts High Partially addressed Emerging 2
OUT-10 Proportional odds, category probabilities, and ordinal utilities High Overstated Emerging 2
OUT-12 Survival extrapolation is unidentified beyond the observed follow-up High Partially addressed Promising 2
OUT-13 Reconstruction uncertainty from digitized Kaplan-Meier curves High Partially addressed Promising 2
OUT-14 Pseudo-IPD cannot express delayed entry or assessment windows High Overstated Emerging 2
OUT-15 Treatment switching and subsequent therapies in survival PAIC High Confirmed open Emerging 2
OUT-16 Competing risks and cumulative incidence transport High Confirmed open Emerging 2
OUT-17 Transition-specific component effects in multistate PAIC High Confirmed open Speculative 2
OUT-18 Component-specific time-varying treatment effects High Partially addressed Emerging 2
OUT-19 No multivariate population-adjusted model for correlated outcomes High Overstated Promising 2
OUT-20 No PAIC workflow carries dependence through transport to net benefit High Partially addressed Emerging 2
OUT-22 No consistency test for vector-valued effects in survival NMA High Partially addressed Promising 2
OUT-23 No estimand aligns outcomes reported on different assessment schedules High Partially addressed Emerging 2
OUT-24 No rule selects the common RMST horizon across unequal follow-up High Partially addressed Promising 2
OUT-25 No treatment-invariance check for summed rating-scale outcomes High Confirmed open Emerging 2
OUT-26 No criterion says when a network supports surrogate-based prediction High Partially addressed Promising 2
OUT-05 Unequal variances, skew, and bounded scales in continuous outcomes Medium-high Confirmed open Promising 3
OUT-06 Change scores, trajectories, and responder-threshold estimands Medium-high Overstated Promising 3
OUT-21 Absolute effects across a network share no baseline risk or time horizon Medium-high Partially addressed Established 3
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