Adjacent-field methods

20 open problems

What optimal transport, targeted learning, federated computation, and other neighbouring fields can and cannot contribute.

ID Problem Priority Verdict Maturity prank
ADJ-01 No transportability-first PAIC workflow matches MAIC’s usability Very high Overstated Promising 1
ADJ-02 No general-purpose transport library plugs into the NMA stack Very high Overstated Promising 1
ADJ-03 Efficient influence-function transport estimators for ITC networks Very high Overstated Promising 1
ADJ-06 Distributionally robust bounds over compatible target laws Very high Confirmed open Promising 1
ADJ-07 Partial identification bounds under drift or omitted modifiers Very high Partially addressed Established 1
ADJ-12 Routine NMA output omits graph diagnostics and value of information Very high Overstated Promising 1
ADJ-14 Federated ML-NMR and federated model checking do not exist Very high Partially addressed Promising 1
ADJ-04 Flexible outcome surfaces and support diagnostics in standardization High Confirmed open Promising 2
ADJ-05 Optimal transport for distributional rather than moment balance High Partially addressed Emerging 2
ADJ-08 Nonparametric and commensurate priors in disconnected evidence High Overstated Promising 2
ADJ-09 Cross-environment invariance as a screen for bridges and modifiers High Confirmed open Promising 2
ADJ-15 Privacy guarantees and governance for shared trial-level data High Partially addressed Emerging 2
ADJ-16 No ITC component vocabulary or datum-level extraction provenance High Confirmed open Emerging 2
ADJ-10 Data-driven modifier and causal-structure discovery with few trials Medium-high Partially addressed Emerging 3
ADJ-18 Simulation-based inference for mechanistic and pharmacometric bridges Medium-high Confirmed open Emerging 3
ADJ-11 No proximal ITC method works with an aggregate-only comparator Medium Partially addressed Speculative 4
ADJ-13 Topology-only graph neural network output cannot identify effects Medium Confirmed open Speculative 4
ADJ-17 Representation learning for low-dimensional population encodings Medium Confirmed open Speculative 4
ADJ-19 Shapley attribution of regimen effects to treatment components Medium Confirmed open Emerging 4
ADJ-20 Reinforcement learning and dynamic regimes for adaptive sequences Medium Partially addressed Speculative 4
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