Computation & reproducibility

8 open problems

Runtime, integration error, prior dependence in weakly identified models, and the analyst choices that never make it into the write-up.

ID	Problem	Priority	Verdict	Maturity	prank
CMU-02	Priors, not data, can drive posteriors in weakly identified models	Very high	Partially addressed	Promising	1
CMU-05	Failed fits are deleted rather than classified and reported	Very high	Partially addressed	Established	1
CMU-08	No cross-package benchmark or reference pipeline for ITC software	Very high	Overstated	Emerging	1
CMU-03	Bayesian component ML-NMR and bridge models lack SBC validation	High	Partially addressed	Established	2
CMU-04	Computational diagnostics and Monte Carlo error go unreported	High	Partially addressed	Established	2
CMU-06	Simulation studies publish no registry, seeds, or environment locks	High	Partially addressed	Established	2
CMU-07	Published PAIC analyses do not record the choices that drive them	High	Partially addressed	Emerging	2
CMU-01	ML-NMR integration cost is unaddressed for flexible survival models	Medium-high	Overstated	Promising	3