Evidence-base construction & data access

15 open problems

Which trials, which comparators, and whose individual patient data — choices that shape the answer before any model is fitted.

ID	Problem	Priority	Verdict	Maturity	prank
EVB-02	Evidence-set assembly can favor the sponsor before modeling begins	Very high	Overstated	Emerging	1
EVB-03	Trials combined under one outcome label are not one estimand	Very high	Partially addressed	Promising	1
EVB-04	No decision-value method chooses which IPD or bridging trial to get	Very high	Partially addressed	Speculative	1
EVB-01	Selective IPD availability threatens transport across the network	High	Partially addressed	Promising	2
EVB-05	No reporting standard covers what population adjustment needs	High	Unverifiable	Emerging	2
EVB-06	No usable correction for overlapping participant populations across studies	High	Confirmed open	Emerging	2
EVB-07	NMA does not model informative trial-design selection	High	Confirmed open	Emerging	2
EVB-09	No common estimand or aggregate-data reconstruction for enriched and withdrawal trials	High	Confirmed open	Emerging	2
EVB-10	No general NMA framework for non-parallel randomized trial designs	High	Confirmed open	Emerging	2
EVB-11	No missing-evidence appraisal for bridged cross-gap contrasts	High	Confirmed open	Emerging	2
EVB-13	Platform trials lack stage-level reporting for network synthesis	High	Partially addressed	Emerging	2
EVB-14	Reporting bias and inconsistency cannot be disentangled in NMA	High	Confirmed open	Promising	2
EVB-08	Network small-study-effects diagnostics lack an assumption-light default	Medium-high	Confirmed open	Established	3
EVB-12	No selective-inference correction for outcome-triggered new trials pooled into NMA	Medium-high	Confirmed open	Emerging	3
EVB-15	Selective non-publication of commissioned indirect comparisons is unmeasured	Medium-high	Confirmed open	Emerging	3

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