Disconnected networks & bridges

21 open problems

When no randomized path exists, some assumption carries the information across the gap. The bridge is the analysis.

ID Problem Priority Verdict Maturity prank
DIS-01 Cross-gap contrasts are absent from the randomized likelihood Very high Confirmed open Established 1
DIS-02 No data-driven criterion can rank candidate bridge families Very high Overstated Emerging 1
DIS-11 Predictive criteria and population comparison cannot validate a bridge Very high Partially addressed Established 1
DIS-12 No standard ledger names the parameter carrying the gap Very high Partially addressed Promising 1
DIS-13 Bridge-ensemble weights cannot be learned for cross-gap accuracy Very high Confirmed open Speculative 1
DIS-14 Reported intervals condition on the bridge being exactly true Very high Partially addressed Promising 1
DIS-15 Cross-gap bridge bounds are not propagated to net benefit Very high Overstated Emerging 1
DIS-16 No design method chooses which edge to add across a disconnected gap Very high Overstated Emerging 1
DIS-03 Baseline risk is not a neutral anchor for disconnected evidence High Overstated Promising 2
DIS-04 Dose-response bridges assume a curve that may not transport High Confirmed open Promising 2
DIS-05 Class-effect bridges extrapolate to treatments with no randomized link High Confirmed open Promising 2
DIS-06 Component additivity across a gap cannot be checked from the data High Unverifiable Promising 2
DIS-07 External-control bridges become cross-design causal synthesis High Partially addressed Promising 2
DIS-09 Structured elicitation is not applied to the cross-gap contrast High Partially addressed Promising 2
DIS-10 multinma’s baseline-synthesis bridge is an unmerged pull request High Confirmed open Emerging 2
DIS-17 Cross-outcome borrowing is a bridge with no diagnostic High Confirmed open Promising 2
DIS-19 No population-adjusted likelihood mixes a randomized core with single-arm evidence High Partially addressed Emerging 2
DIS-20 No aggregate-data bridge exists for disconnected survival networks High Confirmed open Emerging 2
DIS-21 Match acceptance thresholds are uncalibrated against bridge bias High Confirmed open Emerging 2
DIS-08 Mechanistic bridges import structural model error Medium-high Confirmed open Speculative 3
DIS-18 Unequal dose coverage moves a dose-response bridge one way Medium-high Confirmed open Promising 3
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