Baseline characteristics and PASI 75 response for the 15 arms of five
randomized trials in moderate to severe plaque psoriasis: CLEAR, ERASURE,
FEATURE, FIXTURE and JUNCTURE. The trials compare secukinumab at two
doses with placebo, etanercept and ustekinumab, and most have more than
two arms, which makes a small but well connected network for ggnma().
Format
A data frame with 15 rows, one per arm, and 15 columns:
- study
Trial name.
- treatment
Treatment, a factor with placebo first.
- class
Drug class, a factor with four levels.
- n
Participants randomized.
- pasi75_r, pasi75_n
Participants with a PASI 75 response, and the number analyzed.
- age
Mean age in years.
- male
Percentage of men.
- weight
Mean weight in kilograms.
- bmi
Mean body mass index.
- pasi_w0
Mean PASI score at baseline.
- duration
Mean duration of psoriasis in years.
- prior_systemic
Percentage with previous systemic treatment.
- psa
Percentage with psoriatic arthritis.
- reference
The trial's main publication, with its DOI.
Source
Aggregate data compiled by Phillippo (2019) and distributed as
plaque_psoriasis_agd in the 'multinma' package. The analysis that
uses them is Phillippo DM, Dias S, Ades AE, et al. (2020). Multilevel
network meta-regression for population-adjusted treatment comparisons.
Journal of the Royal Statistical Society Series A 183(3): 1189-1210.
doi:10.1111/rssa.12579
. Trial references were checked against PubMed.
Details
Every column except study, treatment and class carries a label
attribute, which ggnma() uses to name the rows of its arm tables.
Examples
psoriasis_nma[c("study", "treatment", "n", "pasi75_r")]
#> study treatment n pasi75_r
#> 1 CLEAR Ustekinumab 339 265
#> 2 CLEAR Secukinumab 300 mg 337 304
#> 3 ERASURE Placebo 248 11
#> 4 ERASURE Secukinumab 150 mg 245 174
#> 5 ERASURE Secukinumab 300 mg 245 200
#> 6 FEATURE Placebo 59 0
#> 7 FEATURE Secukinumab 150 mg 59 41
#> 8 FEATURE Secukinumab 300 mg 59 44
#> 9 FIXTURE Placebo 326 16
#> 10 FIXTURE Etanercept 326 142
#> 11 FIXTURE Secukinumab 150 mg 327 219
#> 12 FIXTURE Secukinumab 300 mg 327 249
#> 13 JUNCTURE Placebo 61 2
#> 14 JUNCTURE Secukinumab 150 mg 61 43
#> 15 JUNCTURE Secukinumab 300 mg 60 52
attr(psoriasis_nma$age, "label")
#> [1] "Mean age (years)"